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Twelfth Grade STEM Curriculum

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🎓 Thesis and Launch: Specialization, Publication and Leadership

An annual plan of 8 missions for twelfth grade, focused on the defense of a research thesis, the launching of startups and ethical mastery.

Main Objective of the Plan

To foster intellectual independence and specialization in twelfth grade students by guiding them through a year-long thesis project from conception to public defense or product launch.

STEM Disciplines and Skills

Science: Computational neuroscience, signal processing (EEG/fMRI), statistics (advanced).
Technology: Programming (Python: MNE-Python, SciPy, Pandas), BCI hardware (OpenBCI - conceptual).
Engineering: Software engineering (real-time data analysis), design of experiments.
Mathematics: Fourier transform, linear algebra (principal component analysis - PCA).


Critical Thinking: What is «mental privacy»? Analyze the ethical risks of BCI.
Collaboration: «Peer review» of another team's experimental design.

Hands-on activities

  • EEG Data Analysis (Python): Use Python (MNE-Python) to load, filter and analyze a public EEG dataset. Identify P300 patterns or alpha/beta rhythms.
  • BCI Experimental Design: Design a complete experimental protocol for a non-invasive BCI (e.g. controlling a drone with thought), including control group and statistical analysis.
  • Discussion: «Neuro-Enhancement» (Enhancement): Debate the ethics of using BCI not to cure, but to «improve» cognition (memory, concentration) in healthy people.
Hybrid/Remote Adaptation (EEG Analysis): Google Colab is ideal for students to run MNE-Python notebooks and collaborate on data analysis.
Google Colab (MNE-Python, SciPy), OpenNeuro (databases), BCI simulators (web).

Formative Evaluation

  • Colab notebook with functional EEG analysis.
  • Experimental design proposal (rubric).
  • Argumentative essay on «neuro-improvement».

Integration of Ethical Values

Mental Privacy: Who owns your thoughts if a BCI can read them?
Agency and Authenticity: If a BCI «improves» you, are you still «you»?
Equity: The gap between the «neuro-enhanced» and the non-enhanced.

STEM Disciplines and Skills

Science: Environmental economics, political science, data science (complex systems modeling).
Technology: Agent-based modeling (NetLogo), GIS (QGIS, Google Earth Engine).
Engineering: Systems engineering (carbon market design), financial engineering (carbon credits).
Mathematics: Game theory (global prisoner's dilemma), optimization.


Systemic Thinking: Analyze the «Tragedy of the Commons» on a global scale and why negotiations (COP) fail.
Data Literacy: Analyze the real price of carbon and its impact on emissions.

Hands-on activities

  • Cap and Trade (NetLogo) simulation: Use NetLogo to model a carbon market. What initial price and cap will achieve emission reductions without bankrupting the industry?
  • Carbon Credits Audit (GIS): Using Google Earth Engine to analyze a reforestation project (selling carbon credits): Is it real? Is it permanent? (Verification).
  • Negotiation Simulation (COP): Assign roles (US, China, EU, India, Brazil, Tuvalu) and negotiate a climate treaty. Use a simulator (e.g. C-ROADS) to see the impact of their pledges.
Hybrid/Remote Adaptation (COP Simulation): It can be done by videoconference, with «breakout rooms» for private negotiations and a shared treaty document.
NetLogo (web), Google Earth Engine, C-ROADS / En-ROADS simulators (web).

Formative Evaluation

  • NetLogo lab report (policy analysis).
  • Carbon credit GIS audit report.
  • Participation (rubric) and results of the COP simulation.

Integration of Ethical Values

Climate Justice: Who should pay for the historical carbon emitted by rich nations?
«Carbon Colonialism: Is it ethical for rich countries to pay poor countries for «not developing» (conserving forests) in exchange for bonuses?

STEM Disciplines and Skills

Science: Data science (time series, machine learning for prediction).
Technology: Programming (Python: Pandas, NumPy, QuantLib, Zipline), auditing of smart contracts.
Engineering: Software engineering (backtesting systems), financial engineering (derivative design).
Mathematics: Statistics (advanced), stochastic calculus (conceptual), cryptography.


Critical Thinking: The «overfitting problem» in backtesting: How to regulate something decentralized (DeFi)?
Planning: Develop a rigorous investment thesis and test it statistically.

Hands-on activities

  • «Backtesting» of Quant Strategy (Python): Develop and backtest a strategy (e.g. statistical arbitrage, pairs) in Python/Colab. Present the results (Sharpe ratio, drawdown).
  • Smart Contract Audit (Reading): Analyze a simple smart contract in Solidity for vulnerabilities (e.g. reentrant, integer overflow).
  • Regulatory Panel: «DAO vs. SEC»: Simulate a hearing. One group is a DAO (e.g. Uniswap) and the other is the SEC. Discuss: Are governance tokens a «security»?
Hybrid/Remote Adaptation (Backtesting): Backtesting at Colab is ideal for remote. Students share their notebooks and peer review each other's code.
Google Colab (Python, Zipline, Pandas), Etherscan, Solidity (reading).

Formative Evaluation

  • Backtesting notebook (with statistical analysis).
  • Smart contract audit report.
  • Arguments and participation in the regulatory panel.

Integration of Ethical Values

Immutability of the Code: Is it ethical that «code is law» in DeFi, even if it allows legal but unfair «hacking»?
Systemic Risk: The responsibility of the «Quants» in financial crises.

STEM Disciplines and Skills

Science: Astrophysics, general relativity (conceptual), data science (signal processing).
Technology: Programming (Python: GWpy, Astropy), interferometer data analysis (LIGO/VIRGO).
Engineering: Detector engineering (laser interferometry - conceptual).
Mathematics: Fourier transform, statistics (signal-to-noise ratio).


Critical Thinking: What do gravitational waves tell us that light cannot?
Creativity: Explain the «fine-tuning» of the universe.

Hands-on activities

  • LIGO Data Analysis (Python): Use a Colab notebook (GWpy) to filter and analyze real LIGO data. Identify the «chirp» (sound) of a black hole merger.
  • Gravitational Lens Modeling: Use a simple simulator (or Python/Astropy) to model how a massive object (black hole) bends the light of a background galaxy (Einstein cross).
  • Debate: The «Fine Tuning» of the Universe: Discuss the implications of «fine-tuning» of physical constants. Is it evidence of a multiverse, design, or luck (anthropic principle)?
Hybrid/Remote Adaptation (LIGO): The LIGO data analysis at Colab is perfect for remote, allowing students to «listen» to the universe.
Google Colab (Python, GWpy, Astropy), LIGO data, relativity simulators.

Formative Evaluation

  • Colab Notebook (with chirp graph and audio).
  • Gravitational lensing simulation.
  • Argumentative essay on «fine tuning».

Integration of Ethical Values

Philosophy of Cosmology: Discuss the limits of the scientific method: Is the «multiverse» a scientific (falsifiable) or metaphysical theory?
Allocation of Funds: The cost of «big science» (LIGO, JWST).

STEM Disciplines and Skills

Science: Advanced genetics (Prime/Base Editing), bioinformatics (gRNA design).
Technology: Genomic design software (Benchling, CRISPResso), databases (NCBI).
Engineering: Bioengineering, design of delivery systems (e.g. AAV, LNP - conceptual).
Mathematics: Statistics (off-target analysis), bioinformatics (sequence alignment).


Critical Thinking: Why is Prime Editing potentially safer than CRISPR-Cas9?
Collaboration: Simulate a hospital ethics committee.

Hands-on activities

  • Design of «Prime Editor» (Benchling): Use Benchling (web) to design a «pegRNA» (Prime Editing guide RNA) to correct a specific mutation (e.g. sickle cell disease).
  • Analysis of «Off-Targets» (Bioinformatics): Use a tool (e.g. NCBI BLAST) to simulate where else the pegRNA might cut in the genome (off-target risks).
  • Ethics Committee (Simulation): Simulating a hospital ethics committee deciding on a real (anonymized) gene therapy case: approve or reject?
Hybrid/Remote Adaptation (Benchling): Benchling pegRNA design is an advanced activity ideal for remote research.
Benchling (web), NCBI BLAST, CRISPResso, papers by David Liu.

Formative Evaluation

  • PegRNA design (with off-target analysis).
  • Off-target audit report (BLAST).
  • Verdict and justification of the ethics committee.

Integration of Ethical Values

Therapy vs. Enhancement: The blurred line between curing a genetic disease and «improving» a trait (e.g., intelligence, height).
Germinal Therapy: The ethics of making heritable genetic changes.

STEM Disciplines and Skills

Science: Data science (AI auditing), cognitive science (reasoning modeling).
Technology: Programming (Python, LLM APIs, Hugging Face), prompts engineering (advanced).
Engineering: Software engineering (RAG, «fine-tuning»), AI safety (AI Safety).
Mathematics: Logic (formalization of statutes), game theory (AI models).


Digital Literacy: «Jailbreaking», «prompt injection», «red teaming».
Critical Thinking: How do you «govern» an AI model? How do you align its goals with human goals?

Hands-on activities

  • «Fine-Tuning» of an LLM (Colab): Use Google Colab and Hugging Face (e.g., LoRA) to fine-tuning a model (e.g., Llama 3, Mistral) on a specific dataset (e.g., poetry, code).
  • «Red Teaming» / Jailbreak of an LLM: In groups, attempt to «break» an AI model (e.g. Gemini, Claude) so that it generates harmful content. Document successful prompts.
  • Drafting of «IA Bylaws»: Draft governance bylaws for an AGI lab (such as OpenAI). For-profit or not-for-profit? Open or closed?
Hybrid/Remote Adaptation (Red Teaming): This can be done asynchronously. Students collaborate on a shared document to find and record the most effective jailbreaks.
Google Colab (Hugging Face), Gemini/Anthropic API, Kialo (web).

Formative Evaluation

  • Fine-tuned model (with analysis of results).
  • Red Teaming Report (with prompts and defenses).
  • IA Governance Charter« document.

Integration of Ethical Values

Power and Control: Who should control the development of AGI: private companies, governments, international consortia?
Transparency: The debate between «Open Source» and «Closed Source» for powerful AI models.

STEM Disciplines and Skills

Science: Planetary science, physics (advanced), materials science.
Technology: Simulation software (Kerbal Space Program), CAD (advanced), Python (calculations).
Engineering: Civil/aerospace engineering (mega-projects), systems engineering.
Mathematics: Calculation (advanced), large-scale cost-benefit analysis.


Creativity: Design a solution to a planetary-scale problem.
Critical (Systemic) Thinking: Analyze the cascading risks of a megaproject (e.g. space elevator).

Hands-on activities

  • Physical Analysis: «Space Elevator»: Use Python/Colab to analyze the physics of a space elevator. Calculate the cable tension and why a material such as carbon nanotubes is needed.
  • Terraforming Plan (Phase 1): In groups, design «Phase 1» of the terraforming of Mars. Present a plan (engineering, costs, schedule) for an objective (e.g. «heat the core», «release CO2»).
  • Debate: Ethics of Terraforming: Do we have the ethical right to «kill» a Martian ecosystem (if microbial life exists) to plant a terrestrial one? (Planetary Protection).
Hybrid/Remote Adaptation (Physical Analysis): Colab's space elevator notebook is a perfect remote physics and engineering activity.
Google Colab (Python), Kerbal Space Program, NASA papers (NIAC), Tinkercad.

Formative Evaluation

  • Colab Notebook (elevator calculations).
  • Terraforming plan proposal (rubric).
  • Argumentative essay on the ethics of terraforming.

Integration of Ethical Values

Planetary Protection: The ethics of contaminating other worlds with terrestrial life.
«Plan B»: Does having a «Plan B» (Mars) make us less responsible for taking care of «Plan A» (Earth)?

STEM Disciplines and Skills

Science: Research methodology (publication level), scientific communication.
Technology: Product development (MVP), version control (Git), publishing (ArXiv).
Engineering: Product life cycle, technical writing (patents), project management (Agile).
Mathematics: Statistical analysis (defense of results), financial projections.


Collaboration: «Peer review and oral defense.
Critical (Systemic) Thinking: Culminate a year's work in a coherent and defensible thesis or product.

Hands-on activities

  • Track 1 (Research): «Thesis Defense»: Complete the paper (started in Grade 11) in LaTeX/Overleaf. Prepare a 20-minute presentation and defend it before a panel.
  • Track 2 (Engineering): «Seed Capital Pitch»: Complete the MVP and pitch deck (started in Grade 11). «Pitch to a panel of »investors« (local professionals) for seed capital.
  • STEM Graduation Symposium: Final event where all students present their thesis (in poster format) or «pitch» their startups (in «Demo Day» format).
Hybrid/Remote Adaptation (Virtual Symposium): Use Overleaf for the thesis and Figma/Canva for the pitch deck. The symposium is videoconferenced, with «breakout rooms» for each project.
Overleaf (LaTeX), ArXiv, GitHub, Figma, Canva, Google Slides.

Formative Evaluation

  • Quality, originality and rigor of the thesis/paper (rubric).
  • Quality of the MVP, business model and pitch (rubric).
  • Oral defense (ability to answer questions).

Integration of Ethical Values

Intellectual Integrity: Honesty about results (even negative).
Intellectual Property: Decide the license of the project (Open Source vs. Patent). Long-Term Vision: Reflect on the ethical impact of their work in the next decade.

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